Genetics by Professor Le Dinh Luong - HTML preview

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Chapter 6Assignments and solutions

Table 6.1. Assignments cover the topics discussed in the corresponding lecture sessions
VN-LEC#MIT-LEC #ASSIGNMENTsSOLUTIONS
3, 23, 29, 30, 321-5Problem Set 1 (PDF)(PDF)
18, 27, 29, 306-9Problem Set 2 (PDF)(PDF)
16, 20-2311-15Problem Set 3 (PDF)(PDF)
24, 2516-19Problem Set 4 (PDF)(PDF)
25-2820-24Problem Set 5 (PDF)(PDF)
33, 2825-30Problem Set 6 (PDF)(PDF)
3131-35Problem Set 7 (PDF)(PDF)

A chromosome:
  • A. is composed of amino acids

  • B. is organized in the nucleus by histones

  • C. is produced from RNA

  • D. is present in 46 pairs in human cells

D. is present in 46 pairs in human cells

Genes:
  • A. never function when they contain a mutation

  • . directly produce proteins

  • C. contain random pairings of nucleotides

  • D. all of the above

  • E. none of the above

E. none of the above

During the process of transcription, genetic information is transferred from:
  • A. DNA to RNA

  • B. RNA to DNA

  • C. DNA to protein

  • D. Protein to RNA

A. DNA to RNA

A mutation that __________ production of a given _________ can manifest as clinical disease.
  • A. increases/protein

  • B. decreases/mRNA

  • C. decreases/ protein

  • D. increases/mRNA

  • E. all of the above

  • F. none of the above

F. none of the above

A mutation occurs that disrupts the normal structure and function of hemoglobin. Which of the following is true?
  • A. clinical disease will develop based on the mutation alone.

  • B. environmental factors can play a large role in the development of clinical disease.

  • C. each person with the same mutation will follow the same clinical course.

  • D. family members should be tested for this hereditary condition.

A. clinical disease will develop based on the mutation alone.

A germline mutation ___________ while a somatic mutation _______________.
  • A. is never passed from parents to offspring // is present in all cells of one’s body

  • B. is always passed from parents to offspring // is present in all cells of one’s body

  • C. is present in all cells of one’s body // is never passed from parents to offspring

  • D. is responsible for non-hereditary cancers // is not often a direct cause of inherited disease

C. is present in all cells of one’s body // is never passed from parents to offspring

A missense mutation
  • A. does not affect protein structure

  • B. does not affect protein function

  • C. leads to substitution of an amino acid in a new place in the protein

  • D. all of the above

  • E. none of the above

C. leads to substitution of an amino acid in a new place in the protein

A nonsense mutation
  • A. does not affect protein structure

  • B. may not lead to clinical disease

  • C. involves an inappropriate stop codon

  • D. A and B

  • E. A and C

  • F. All of the above

C. involves an inappropriate stop codon

A silent mutation
  • A. results in no change in protein structure/function

  • B. can sometimes lead to clinical disease

  • C. involves substitution of one amino acid for another

  • D. A and C

  • E. A and B

A. results in no change in protein structure/function

A polymorphism is a form of mutation that leads to clinical disease.
  • True

  • Flase

False
Solutions