PCO support the collagen and ground substance of tendons, ligaments and cartilage. They also help to prevent
cartilage destruction associated with inflammation and arthritis. PCO also inhibit the release of pro-inflammatory
mediators such as histamine, proteases, prostaglandins and leukotrienes. PCO also demonstrate powerful
antioxidant function. No clinical trials with arthritis patients have been published, however, anecdotal evidence and
biological plausibility suggest that PCO extract supplementation may be useful in chronic arthritic and connective
tissue disorders.10,11,12