Oral contraceptives reduce the nutritional status of manganese, as well as magnesium and vitamin B6.
There are no other well-known drug-nutrient interactions for manganese.
Nutrient-Nutrient Interactions
Calcium: calcium competes with manganese for absorption, thus high intake of one can reduce absorption of the
other.viii
Iron: iron competes with manganese for absorption, thus high intake of one can reduce absorption of the other.ix
Copper: high copper intake reduces absorption of manganese.viii
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Meschino Health Comprehensive Guide to Minerals
Pregnancy and Lactation
During pregnancy and lactation, the only supplements that are considered safe include standard prenatal
vitamin and mineral supplements. All other supplements or dose alterations may pose a threat to the
developing fetus and there is generally insuf icient evidence at this time to determine an absolute level of
safety for most dietary supplements other than a prenatal supplement. Any supplementation practices
beyond a prenatal supplement should involve the cooperation of the at ending physician (e.g., magnesium
and the treatment of preeclampsia.)
References: Pregnancy and Lactation
1. Encyclopedia of Nutritional Supplements. Murray M. Prima Publishing 1998.
2. Reavley NM. The New Encyclopedia of Vitamins, Minerals, Supplements, and Herbs. Evans and
Company Inc. 1998.
3. The Healing Power of Herbs (2nd edition). Murray M. Prima Publishing 1995.
4. Boon H and Smith M. Health Care Professional Training Program in Complementary Medicine.
Institute of Applied Complementary Medicine Inc. 1997.
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Meschino Health Comprehensive Guide to Minerals
1. Standard Textbooks of Nutritional Science:
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Shils M, Shike M, Olson J and Ross C. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Lippincott Williams
& Wilkins; 1993.
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Escott-Stump S and Mahan LK, editors. Food, Nutrition and Diet Therapy. 10th ed. Philadelphia, PA: W.B. Saunders
Company; 2000.
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Bowman B and Russell RM, editors. Present Knowledge in Nutrition, 8th ed. Washington, DC:.ILSI Press; 2001.
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Kreutler PA and Czajka-Narins DM, editors. Nutrition in Perspective. 2nd ed. Upper Saddle River, NJ: Prentice Hall Inc.;