Selenium supplementation at 200 mcg per day has been shown to stimulate white blood cell and thymus function.
Increased killer cell activity and other parameters of heightened immune function have been shown even in
otherwise healthy patients. Some of the ef ect appears to be mediated through increased expression of the
immune-enhancing interleukin-2. This in turn increases the rate of white blood cell proliferation and differentiation
into more capable immune system leukocytes.13,14,15
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Meschino Health Comprehensive Guide to Minerals
Selenium supplementation has also been able to significantly increase glutathione levels and activity in HIV-positive
patients. Reduction in glutathione levels in these patients carries a poor prognosis for the progression of HIV to
AIDS.16,17
3. Cardiovascular Disease (CVD)
Epidemiological evidence suggests that CVD increases as selenium intake decreases. As noted earlier, Keshan
disease is primarily caused by sub-optimal blood levels of selenium (< 1 mcg/ml) vs. more normal values (19-25
mcg/ml).7
Through antioxidant activation, it may help to reduce LDL-cholesterol oxidation and may also improve the HDL-to-
LDL ratio and reduce blood platelet aggregation.
In a double-blind study, one milligram (1,000 mcg) of selenium and 200 I.U. of Vitamin E daily produced significant
relief from angina pain vs. placebo. However, this is preliminary evidence only.18