Mitochondria – Cell organelles that
Austad, S.N., “Comparative Biology of Aging,” Journal of
produce energy necessary for life from the
Gerontology: Biological Sciences, 64A(2): 199-201, 2009.
foods we eat. Mitochondria contain DNA,
Bartke, A., “Insulin and Aging,” Cell Cycle, 7(21):
which may be damaged by oxygen free radi-
3338-3343, 2008.
cals produced during this process. Damage
of mitochondrial DNA may contribute to
Bartke, A., “The Somatotropic Axis and Aging: Mechanisms
and Persistent Questions about Practical Implications,”
aging. Mitochondria also are involved in
Experimental Gerontology, 44(6-7): 372-374, 2009.
controlling cell death.
Barzilai, N. and Bartke, A., “Biological Approaches to
Proteins – Molecules arranged in a specific
Mechanistically Understand the Healthy Life Span Exten-
order determined by DNA. Proteins are
sion Achieved by Calorie Restriction and Modulation of
Hormones,” Journal of Gerontology: Biological Sciences,
essential for all life processes. Certain proteins,
64A(2): 187-191, 2009.
such as those protecting against free radicals
and those produced by the immune system,
Bauer, M.E., “Chronic Stress and Immunosenescence: A
are studied extensively by gerontologists.
Review,” NeuroImmunoModulation, 15: 241-250, 2008.
Baur, J.A., Pearson, K.J., Price, N.L., et al., “Resveratrol
Stem cells – Cells with the potential
Improves Health and Survival of Mice on a High-Calorie
to become many different types of cells
Diet,” Nature, 444: 337-342, 2006.
found in the body. Stem cells are also able
Blagozklonny, M.V. and Campisi, J., “Cancer and Aging,”
to replicate almost indefinitely without
Cell Cycle, 7(17): 2615-2618, 2008.
becoming abnormal.
Buffenstein, R., “The Naked Mole-Rat: A New Long-Living
Telomerase – An enzyme that restores
Model for Human Aging Research,” Journal of Gerontology:
telomeres to the ends of chromosomes in
Biological Sciences, 60A(11): 1369-1377, 2005.
certain cells, such as egg and sperm cells. This
Calvanese, V., Lara, E., Kahn, A., and Fraga, M.F., “The Role
telomere lengthening insures that the cells
of Epigenetics in Aging and Age-Related Diseases,” Ageing
can continue to divide and multiply.
Research Reviews, 8: 268-276, 2009.
Telomeres – Repeated short, non-coding
Campisi, J. and Yaswen, P., “Aging and Cancer Cell Biology,
2009,” Aging Cell, 8: 221-225, 2009.
sequences of DNA at each end of a chromo-
some. Telomeres protect the chromosome from
Centers for Disease Control and Prevention,
damage and shorten each time a cell divides.
Health, United States, 2008, p. 208, http://www.cdc.gov/
nchs/data/hus/hus08.pdf#026
BIOLOGY OF AGING: RESEARCH TODAY FOR A HEALTHIER TOMORROW 37
BIBLIOGRAPHY (continued)
Chen, W.H., Kozlovsky, B.F., Effros, R.B., et al., “Vaccination Garinis, G.A., van der Horst, G.T.J., Vijg, J., and Hoeijmakers, in the Elderly: An Immunological Perspective,” Trends in
J.H.J., “DNA Damage and Ageing: New-Age Ideas for an Age-
Immunology, 30(7): 351-359, 2009.
Old Problem,” Nature Cell Biology, 10(11): 1241-1247, 2008.
Christensen, K., Doblhammer, G., Rau, R., and Vaupel, J.W.,
Geiger, H. and Rudolph, K.L., “Aging in the Lympho-hema-
“Ageing Populations: The Challenges Ahead,” Lancet, 374:
topoietic Stem Cell Compartment,” Trends in Immunology,
1196-1208, 2009.
30(7): 360-365, 2009.
Christensen, K., McGue, M., Petersen, I., et al., “Exceptional Globerson, A. and Barzilai, N., “The Voyage to Healthy
Longevity Does Not Result in Excessive Levels of Disability,”
Longevity: From Experimental Models to the Ultimate
Proceedings of the National Academy of Sciences, 105(36):
Goal,” Mechanisms of Ageing and Development, 126:
13274-13279, 2008.
225-229, 2005.
Colman, R.J., Anderson, R.M., Johnson, S.C., et al., “Calorie
Guarente, L., “Sirtuins in Aging and Disease,” Cold Spring
Restriction Delays Disease Onset and Mortality in Rhesus
Harbor Symposia on Quantitative Biology, 72: 483-488, 2007.
Monkeys,” Science, 325: 201-204, 2009.
Guevara-Aguirre, J., Balasubramanian, P., Guevara-Aguirre,
Cox, L.S. and Mattison, J.A., “Increasing Longevity through
M., et al., “Growth Hormone Receptor Deficiency Is Associ-
Caloric Restriction or Rapamycin Feeding in Mammals:
ated with a Major Reduction in Pro-Aging Signaling, Cancer,
Common Mechanisms for Common Outcomes?”
and Diabetes in Humans,” Science Translational Medicine,
Aging Cell, 8: 607-613, 2009.
3(70): 70ra13, 2011.
Cuervo, A.M., “Autophagy and Aging: Keeping that Old
Hadley, E.C., Lakatta, E.G., Morrison-Bogorad, M., et al.,
Broom Working,” Trends in Genetics, 24(12): 604-612, 2008.
“The Future of Aging Therapies,” Cell, 120: 557-567, 2005.
Harrison, D.E., Strong, R., Sharp, Z.D., et al., “Rapamycin
Cuervo, A.M., “Calorie Restriction and Aging: The Ultimate
Fed Late in Life Extends Lifespan in Genetically Heteroge-
‘Cleansing Diet,’” Journal of Gerontology: Biological
neous Mice,” Nature, 460: 392-395, 2009.
Sciences, 63A(6): 547-549, 2008.
Herbig, U., Ferriera, M., Condel, L., et al., “Cellular
DiCarlo, A.L., Fuldner, R., Kaminski, J., and Hodes, R., “Aging Senescence in Aging Primates,” Science, 311: 1257, 2006.
in the Context of Immunological Architecture, Function
and Disease Outcomes,” Trends in Immunology, 30(7): 293-
Hildt, E., “Living Longer: Age Retardation and Autonomy,”
294, 2009.
Medicine, Health Care, and Philosophy, 12(2): 179-185, 2009.
Finch, C.E., “Update on Slow Aging and Negligible Senes-
Kennedy, B.K., “The Genetics of Ageing: Insight from
cence—A Mini-Review,” Gerontology, 55: 307-313, 2009.
Genome-Wide Approaches in Invertebrate Model Organ-
isms,” Journal of Internal Medicine, 263: 142-152, 2008.
Fraga, M.F., Ballestar, E., Paz, M.F., et al., “Epigenetic Differences Arise During the Lifetime of Monozygotic Twins,”
Khrapko, K. and Vijg, J., “Mitochondrial DNA Mutations
Proceedings of the National Academy of Sciences, 102(30):
and Aging: Devils in the Details?” Trends in Genetics, 25(2):
10604-10609, 2005.
91-98, 2009.
38
Kirkwood, T.B.L., “Understanding the Odd Science of Aging,”
Ostan, R., Bucci, L., Capri, M., et al., “Immunosenescence and Cell, 120: 437-447, 2005.
Immunogenetics of Human Longevity,” NeuroImmuno-
Modulation, 15: 224-240, 2008.
Leslie, M., “Searching for the Secrets of the Super Old,”
Science, 321: 1764-1765, 2008.
Panda, A., Arjona, A., Sapey, E., et al., “Human Innate Immu-
nosenscence: Causes and Consequences for Immunity in
Martin, G.M., Bergman, A., and Barzilai, N., “Genetic Deter-
Old Age,” Trends in Immunology, 30(7): 325-333, 2009.
minants of Human Health Span and Life Span: Progress and
New Opportunities,” PLoS Genetics, 3(7): 1121-1130, 2007.
Pawlikowska, L., Hu, D., Huntsman, S., et al., “Association
of Common Genetic Variation in the Insulin/IGF-1
Mattison, J.A., Roth, G.S., Lane, M.A., and Ingram, D.K.,
Signaling Pathway with Human Longevity,” Aging Cell,
“Dietary Restriction in Aging Nonhuman Primates” in
8: 260-472, 2009.
Mobbs, C.V., Yen, K., Hof, P.R. (eds): Mechanisms of Dietary
Restriction in Aging and Disease. Interdisciplinary Topics
Pearson, K.J., Baur, J.A., Lewis, K.N., et al., “Resveratrol Delays in Gerontology. Basel, Karger, 35: 137-158, 2007.
Age-Related Deterioration and Mimics Transcriptional
Aspects of Dietary Restriction without Extending Life Span,”
Mattson, M., “Dietary Factors, Hormesis and Health,”
Cell Metabolism, 8: 157-168, 2008.
Ageing Research Reviews, 7: 43-48, 2008.
Pedersen, P.L., “Mitochondrial Matters of the Heart:
Mattson, M., “Energy Intake, Meal Frequency, and
A Plethora of Regulatory Modes to Maintain Function
Health: A Neurobiological Perspective,” Annual Review
for a Long Lifetime,” Journal of Bioenergetics and
of Nutrition, 25: 237-260, 2005.
Biomembranes, 41: 95-98, 2009.
Maue, A.C., Yager, E.J., Swain, S.L., et al., “T cell Immuno-
Pérez, V.I., Buffenstein, R., Masamsetti V., et al., “Protein Sta-senescence: Lessons Learned from Mouse Models of Aging,”
bility and Resistance to Oxidative Stress Are Determinants
Trends in Immunology, 30(7): 301-305, 2009.
of Longevity in the Longest-Living Rodent, the Naked Mole
McElhaney, J.E. and Effros, R.B., “Immunosenescence:
Rat,” Proceedings of the National Academy of Sciences, 106:
What Does It Mean to Health Outcomes in Older Adults?”
3059-3064, 2009.
Current Opinion in Immunology, 21: 418-424, 2009.
Perls, T., “The Different Paths to Age One Hundred,” Annals
Melzer, D., “Genetic Polymorphisms and Human Aging:
of the New York Academy of Sciences, 1055: 13-25, 2005.
Association Studies Deliver,” Rejuvenation Research, 11(2):
Perls, T., Kunkel, L., and Puca, A., “The Genetics of Aging,”
523-526, 2008.
Current Opinion in Genetics & Development, 12:
Michan, S. and Sinclair, D., “Sirtuins in Mammals: Insights
362-369, 2002.
into Their Biological Function,” Biochemical Journal, 404:
1-13, 2007.
Rama, P., Matuska, S., Paganoni, G., et al., “Limbal Stem-Cell Therapy and Long-Term Corneal Regeneration,” The New
Narasimhan, S.D., Yen, K., and Tissenbaum, H.A., “Converg-
England Journal of Medicine, 363: 147-155, 2010.
ing Pathways in Lifespan Regulation,” Current Biology,
19(15): 657-666, 2009.
BIOLOGY OF AGING: RESEARCH TODAY FOR A HEALTHIER TOMORROW 39
Reddien, P.W., Bermange, A.L., Murfitt, K.J., et al., “Identification of Genes Needed for Regeneration, Stem Cell Function,
and Tissue Homeostasis by Systematic Gene Perturbation
in Planaria,” Developmental Cell, 8: 635-649, 2005.
Salmon, A.B., Leonard, S., Masamsetti, V., et al., “The Long
Lifespan of Two Bat Species Is Correlated with Resistance
to Protein Oxidation and Enhanced Protein Homeostasis,”
The Journal of the Federation of American Societies for
Experimental Biology, 23: 2317-2326, 2009.
Sierra, F., “Biology of Aging Summit Report,” Journal of
Gerontology: Biological Sciences, 64A(2): 155-156, 2009.
Sierra, F., Hadley, E., Suzman, R., and Hodes, R., “Prospects
for Life Span Extension,” Annual Review of Medicine, 60:
457-469, 2009.
Stanfel, M.N., Shamieh, L.S., Kaeberlein, M., and Kennedy,
B.K., “The TOR Pathway Comes of Age,” Biochimica et
Biophysica Acta, 1790: 1067-1074, 2009.
Strong, R., Miller, R.A., Astle, C.M., et al., “Nordihydroguari-arietic Acid and Aspirin Increase Lifespan of Genetically
Heterogeneous Male Mice,” Aging Cell, 7: 641-650, 2008.
Swain, S.L. and Nikolich-Zugich, J., “Key Research Opportu-
nities in Immune System Aging,” Journal of Gerontology:
Biological Sciences, 64A(2): 183-186, 2009.
Terry, D.F., Nolan, V.G., Andersen, S.L., et al., “Association of Longer Telomeres With Better Health in Centenarians,”
Journal of Gerontology: Biological Sciences, 63A(8):
809-812, 2008.
Tower, J., “Hsps and Aging,” Trends in Endocrinology
and Metabolism, 20(5): 216-222, 2009.
Vijg, J. and Campisi, J., “Puzzles, Promises and a Cure
for Aging,” Nature, 454(7208): 1065-1071, 2008.
Willer, C.J., Sanna, S., Jackson, A.U., et al., “Newly Identified Loci that Influence Lipid Concentrations and Risk of
Coronary Artery Disease,” Nature Genetics, 40(2):
161-169, 2008.
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TON, D
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