Using Technology to Understand Cellular and Molecular Biology by National Institute of Health. - HTML preview

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2.

Do students have maximum information about the roll? Is there

anything they do not know about the bread roll from just looking

at it?

Student responses will vary from, “Is it tasty?” and “Where does it

come from?” to “What is inside?” Some students may realize that

although they might have made an assumption about the roll’s inte-

rior (for example, it is just plain bread), they actually know noth-

ing about what is under the crust.

3.

Focus discussion on what is inside the bread roll. Ask students

how they would get that information.

Students will suggest cutting

or tearing the roll.

4.

Slice the roll to reveal the

presence of dye in one of

the two dye locations. Hold

the roll so the class can see

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Molecular Biology

the two cut edges. Do the students now feel they have complete

information about this object? If not, what questions do they have?

Even though they know there is a dyed region inside the roll, stu-

dents should realize that they do not know what this region looks

like. What is the shape of the dyed region and how far does it

extend in any given direction? Is there only a single dyed region, or

are there multiple regions? If there is more than one dyed region, is

it the same color as the region they can see?

Tip from the field test: Some students suggested cutting the roll as

one would if making a sandwich. The second bread roll is helpful if

this possibility is raised.

5.

Ask students how they could obtain information to answer these

questions.

A simple approach would be to make additional slices in the roll.

Students may suggest more exotic means (for example, use a fiber

optic light source connected to a minivideo device to view the roll’s

interior on a remote screen). If suggestions fall in the latter cat-

egory, congratulate students for their ingenuity. Ask them to think

about how to gain the information required quickly and using

simple, available technology. In the end, focus student attention on

increasing the number of slices. This requires only a knife and can

be done quickly.

6.

Ask the students how many slices would be required to define

the dyed region(s) in the roll’s interior. What are their consider-

ations in providing an answer to this question?

The actual number of slices that the students believe is correct is

not the important issue. If students do provide a specific answer,

ask them to justify it. It is important for them to understand the

following. First, multiple slices are required to define the object’s

properties. The size of the slices will determine the resolution used

to define the object’s properties. Thicker slices will provide less res-

olution, just as the 3 × 3 probes provided low resolution in Activity

1. Thinner slices will provide greater resolution, just as the 1 × 1

probes did in Activity 1.

7.

Ask students to have their group’s Master 2.3 to 2.8 available.

Explain that the “level” designation below the grid (Level 1, 2, 3,

4, 5, or 6) on the master indicates the location of a slice through

an object.

Level 1 is the top slice, followed by 2, 3, 4, 5, and 6 (at the bot-

tom).

64

index-75_1.png

index-75_2.png

8.

Ask students to visualize their pattern in three dimensions by

imagining that their shaded pattern represents the top of a stack

of gray blocks. Their level is a slice two blocks thick.

9.

Ask the groups to share their data (that is, the location of the

shaded regions) and try to reconstruct the three-dimensional

object that has been cut into six slices.

Do not provide additional guidance. Give students about five min-

utes to do this. Students may or may not be able to reconstruct the

object in this time.

For those using the Web version of this activity, proceed as

follows:

10. Were students able to arrive at a solution? What might

have made the task of reconstructing the object in three dimen-

sions easier?

Content Standard E:

Identify a problem or

Students might suggest that a computer could provide the technol-

design an opportunity.

ogy to make reconstruction easier.

Content Standard E:

11. Have students proceed to the URL http://science.education.nih.gov/

Implement a proposed

supplements/technology/student. Students should then click on the solution.

link to “Lesson 2—Solution to Probing for Answers.” This brings

up the unit’s desktop, from which students can access this activity. Content Standard A: 12. Students can enter their data by first selecting a level (1 to 6) and Scientists rely on tech-then clicking on the squares they determined to be shaded. The

nology to enhance

reconstructed object will appear as data are entered.

gathering and manipu-

lating data.

It may be easier and less time consuming for the teacher to enter

the data provided by the students.

For those using the print version of this activity, proceed as

follows:

10. Show students a transparency of Master 2.9, Solution

to Probing for Answers. Were they able to arrive at this

Content Standard E:

solution? What might have made their task easier?

Identify a problem or

design an opportunity.

Some students do well thinking in three dimensions, and others do

not. Many may recognize the need for additional technology, such

as a computer and appropriate software, to make the job of recon-

struction easier. Even a simple technology, such as wooden blocks

or Legos, could have been used to construct a three-dimensional

model of the intact object.

65

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How Your

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echnology to Study What Your

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and Hears

Molecular Biology

Discussion Question

1.

As a follow-up, ask students, “Have these activities expanded

your understanding of technology? If they have, how?”

Assessment:

Activity 1 demonstrates the use of multiple probes to achieve dif-

This question allows

ferent levels of resolution. It also demonstrates that the right tool,

students to integrate

in this case a probe of appropriate size, must be selected to solve a

the information they

problem (resolving the structure of an unknown object). Therefore,

have learned in the

students should realize that there is an appropriate technology for

first two lessons and

a given problem (that is, the right tool for the job). Activity 2 dem-

refine their under-

onstrates that solutions to a problem may involve more than one

standing of what tech-

technology (the use of slices to determine the structure of a three-

nology is.

dimensional object and technologies to collect and analyze the data).

66

Lesson 2 Organizer: Web Version

Activity 1: Probing for Answers

What the Teacher Does

Procedure Reference

State or write on the board, “Technology is a means of extend-

Pages 57–58

ing human potential or of extending human senses.”

Steps 1–3

• Ask students if they agree with this statement.

• Ask students to provide justification for their responses.

Can they relate specific technologies to the extension of

specific human attributes or senses?

• Ask students to consider technologies that have

increased our understanding of living systems.

o Do they extend any human attributes?

o If they do, which attributes are extended?

Ask students to focus on technologies (the eye, microscopes,

Page 58

X-ray techniques) that allow us to see biological objects. Ask,

Steps 4–6

• “What technologies would you use to study a whole

organism and why?”

• “What technologies would you use to study cells and

why?”

• “What techniques would you use to study molecules and

why?”

• “Why can’t a single technology provide information at all

levels of organization of biological organisms?”

Introduce the concept of resolution. Ask students what resolu-

tion means.

Tell students that they will investigate resolution. Organize the

Pages 59–60

class into groups of two and then pair two groups.

Steps 7–11

• Arrange seating so that one group sits opposite the

other.

• Explain that the activity resembles the game Battleship.

• Each group’s task is to locate and define the shape of

an object or objects on the master held by the opposing

group.

• Give each group a copy of Master 2.1, Probing for

Answers Score Sheet.

• Use a transparency of this master to demonstrate how

the activity is done.

67

Student

Student L

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How Y

Using our

T Brain Understands

echnology to Study What Your

Cellular Ear

and Hears

Molecular Biology

Begin the activity.

Pages 60–62

• Give each group one master selected from Masters 2.3

Steps 12–20

to 2.8, Probing for Answers—Levels 1–6.

• Give each group a 3 × 3 probe from Master 2.2, Probes.

Instruct students to use this probe to locate areas 3

squares by 3 squares that contain the opposing group’s

shaded object(s).

• After five minutes, ask students if they have enough

information to specify the exact shape(s) and location(s)

of the opposing group’s shaded object(s).

• Ask students what would help them define the shape

and location of the opposing group’s shaded object(s).

• Give each group a 2 × 2 probe and ask them to refine

their search with this probe.

• After several minutes, ask students if they believe they

now have enough information to specify the exact

shape(s) and location(s) of the opposing group’s shaded

object(s).

• Give each group a 1 × 1 probe and ask them to refine

their search with this probe.

• After several minutes, ask students if they believe they

now have enough information to specify the exact

shape(s) and location(s) of the opposing group’s shaded

object(s). Do they need another probe to complete their

task?

• Have opposing groups confirm that after using the series

of three probes, they were able to determine the correct

pattern on one another’s master. Proceed to discussion

questions.

Activity 2: More Than Meets the Eye

What the Teacher Does

Procedure Reference

Hold a bread roll into which you have inserted food dye up to

Pages 63–64

the class.

Steps 1–6

• Ask students to describe what they see.

• Is there anything about the roll they do not know from

just looking at it?

• Focus discussion on what is inside the roll and ask stu-

dents how they would get that information.

• Slice the roll to reveal the dye.

• Ask students if they feel that they now have complete

information about the object.

• What additional questions do they have and how could

they get the answers?

• How many slices are required to define the dyed

region(s) in the roll’s interior? Focus discussion on

resolution.

68

Ask students to have their Master 2.3 to 2.8 available.

Pages 64–65

• Explain that the “level” designation on the master indi-

Steps 7–10

cates the location of a slice through an object (1 at the

top to 6 at the bottom).

• Ask students to visualize their pattern in three dimen-

sions by imagining that their shaded pattern represents

the top of a stack of grey blocks. Their level is a slice two

blocks thick.

• Ask the groups to share their data (that is, the location

of the shaded regions) and try to reconstruct the three-

dimensional object that has been cut into six slices.

• Ask if students were able to arrive at a solution. What

might have made their task easier?

Have students click on “Lesson 2—Solution to Probing for

Page 65

Answers” and then click on the link to “Solution to Probing

Steps 11–12

for Answers.” Have students enter their data to reconstruct the

object.

= Involves copying a master.

= Involves using the Internet.

= Involves using a transparency.

69

Student

Student L

L essons

esson 2

How Y

Using our

T Brain Understands

echnology to Study What Your

Cellular Ear

and Hears

Molecular Biology

Lesson 2 Organizer: Print Version

Activity 1: Probing for Answers

What the Teacher Does

Procedure Reference

State or write on the board, “Technology is a means of extend-

Pages 57–58

ing human potential or of extending human senses.”

Steps 1–3

• Ask students if they agree with this statement.

• Ask students to provide justification for their responses.

Can they relate specific technologies to the extension of

specific human attributes or senses?

• Ask students to consider technologies that have

increased our understanding of living systems.

o Do they extend any human attributes?

o If they do, which attributes are extended?

Ask students to focus on technologies (the eye, microscopes,

Page 58

X-ray techniques) that allow us to see biological objects. Ask,

Steps 4–6

• “What technologies would you use to study a whole

organism and why?”

• “What technologies would you use to study cells and

why?”

• “What techniques would you use to study molecules and

why?”

• “Why can’t a single technology provide information at all

levels of organization of biological organisms?”

Introduce the concept of resolution, Ask students what resolu-

tion means.

Tell students that they will investigate resolution. Organize the

Pages 59–60

class into groups of two and then pair two groups.

Steps 7–11

• Arrange seating so that one group sits opposite the

other.

• Explain that the activity resembles the game Battleship.

• Each group’s task is to locate and define the shape of

an object or objects on the master held by the opposing

group.

• Give each group a copy of Master 2.1, Probing for

Answers Score Sheet.

• Use a transparency of this master to demonstrate how

the activity is done.

70

Begin the activity.

Pages 60–62

• Give each group one master selected from Masters 2.3

Steps 12–20

to 2.8, Probing for Answers—Levels 1–6.

• Give each group a 3 × 3 probe from Master 2.2, Probes.

Instruct students to use this probe to locate areas 3

squares by 3 squares that contain the opposing group’s

shaded object(s).

• After five minutes, ask students if they have enough

information to specify the exact shape(s) and location(s)

of the opposing group’s shaded object(s).

• Ask students what would help them define the shape

and location of the opposing group’s shaded object(s).

• Give each group a 2 × 2 probe and ask them to refine

their search with this probe.

• After several minutes, ask students if they believe they

now have enough information to specify the exact

shape(s) and location(s) of the opposing group’s shaded

object(s).

• Give each group a 1 × 1 probe and ask them to refine

their search with this probe.

• After several minutes, ask students if they believe they

now have enough information to specify the exact

shape(s) and location(s) of the opposing group’s shaded

object(s). Do they need another probe to complete their

task?

• Have opposing groups confirm that after using the series

of three probes, they were able to determine the correct

pattern on one another’s master. Proceed to discussion

questions.

Activity 2: More Than Meets the Eye

What the Teacher Does

Procedure Reference

Hold a bread roll into which you have inserted food dye up to

Pages 63–64

the class.

Steps 1–6

• Ask students to describe what they see.

• Is there anything about the roll they do not know from

just looking at it?

• Focus discussion on what is inside the roll and ask stu-

dents how they would get that information.

• Slice the roll to reveal the dye.

• Ask students if they feel that they now have complete

information about the object.

• What additional questions do they have and how could

they get the answers?

• How many slices are required to define the dyed

region(s) in the roll’s interior? Focus discussion on

resolution.

71

Student

Student L

L essons

esson 2

How Y

Using our

T Brain Understands

echnology to Study What Your

Cellular Ear

and Hears

Molecular Biology

Ask students to have their Master 2.3 to 2.8 available.

Pages 64–65

• Explain that the “level” designation on the master indi-

Steps 7–10

cates the location of a slice through an object (1 at the

top to 6 at the bottom).

• Ask students to visualize their pattern in three dimen-

sions by imagining that their shaded pattern represents

the top of a stack of grey blocks. Their level is a slice two

blocks thick.

• Ask the groups to share their data (that is, the location

of the shaded regions) and try to reconstruct the three-

dimensional object that has been cut into six slices.

• Show students a transparency of Master 2.9, Solution to

Probing for Answers.

• Ask if students were able to arrive at this solution. What

might have made their task easier?

= Involves copying a master.

= Involves using a transparency.

72

Lesson 3

Explore

Explain

Putting Technology

Elaborate

to Work

Overview

At a Glance

This lesson consists of a single activity with three parts in the Web ver