Approach to Constipation
Constipation is a symptom and is not a disease
Constipation is the most common digestive complaint. It affects around 27 % of the population.
Constipation is more common in women and the elderly
Signs and Symptoms (definition)
ROME-IV criteria for constipation: in a patient who does not take laxatives or have Irritable Bowel Syndrome, patient has at least two of the following over the preceding three months:
Pathophysiology:
Primary causes: |
Secondary causes |
1. normal transit (the most common): chronic functional (idiopathic) 2. outlet dysfunction: (defecation disorders, pelvic floor dysfunction) can be due to dyssynergia, excessive or inadequate perineal descent, rectal prolapse, anal stricture or fissure, hyposensitivity, rectocele 3. slow transit: due to a reduced number of neurons within the myenteric plexus and/or interstitial cells of Cajal and increased intestinal collagen deposition. |
Drugs: opiates,anticholinergic, antidepressant, antihistamine, anti- Parkinsonian, iron, calcium, calcium channel blockers, opiates. Neurogenic: autonomic neuropathy, Parkinson’s disease, multiple sclerosis, CNS and spinal cord lesions, diabetes mellitus, pelvic nerve damage Hormonal or endocrine disorders: hypothyroidism Lifestyle : low fiber in diet, dehydration, immobility |
Investigations:
Laboratory: KFT, electrolytes, RBS, TSH
Colonoscopy
CT abdominal, pelvis
Dynamic pelvic floor magnetic resonance defectography
Colonic transit studies
Management
Most patients with constipation are initially managed with lifestyle changes including regular exercise, avoidance of constipating medications, and access to toileting.
The use of dietary fiber and hydration has been the mainstay of therapy in chronic constipation.
Laxatives:
1) Chloride channel activators (lubiprostone;) increases fluid content of stool
2) Bulking agents, fiber supplements
3) Stimulants: causes contraction of intestines, can cause dependency (Senna, bisacodyl)
4) Osmotics: increase water in intestines (Lactulose)
5) Stool softeners: moisture to stool (Colace)
6) Lubricants: grease stool for ease of expulsion (mineral oil); lubricants may decrease absorption of other medications and/or nutrients
7) 5-HT-4 agonists: (prucalopride); increase fluid secretion in the intestines and decrease colonic transit time.
Physiotherapy Intervention
1. Pelvic floor muscle exercises/training
2. Manual therapy:
a. Mobilize sacrococcygeal joint, release pain and trigger points in pelvic floor and coccygeus muscles
3. Abdominal muscle coordination training
4. Bowel training; defecation posture instruction
5. Abdominal massage